Executive Director, Clinical Pharmacology/Pharmacometrics

Your work will change lives. Including your own.

The Impact You'll Make

You will join an innovative and passionate clinical development team dedicated to improving the lives of patients suffering from devastating diseases.  You will lead the innovative clinical pharmacology and pharmacometrics strategy and execution for a portfolio of rare disease and oncology clinical programs.

In this role, you will

• Develop the clinical pharmacology and pharmacometric strategies to accelerate and support the overall product development plan. You’ll be the Clinical Pharmacology lead for various programs in clinical development, the representative for regulatory interactions, and propose innovative strategies to get therapies to patients faster.

• Solve drug development questions/problems by performing and/or overseeing modeling and simulation with various tools to expedite decision making.

• Design  clinical studies. You’ll provide (clinical) pharmacology input on all clinical study designs, from Phase 1-3 and dedicated Phase 1 clinical pharmacology studies.

• Author review relevant clinical pharmacology sections for regulatory documents, including Investigator's Brochures (IB), INDs, NDAs, and other regulatory submissions. Act as the clinical pharmacology expert during interactions with health authorities.

• Interface with cross-functional teams. You’ll work closely with clinical study teams, translational teams (DMPK, Translational Modeling and Toxicology), preclinical teams and due diligence teams to ensure clinical pharmacology-related considerations are addressed.

The Team You’ll Join

You will join the Pharmacometrics team within the company comprising clinical pharmacology, pharmacometrics, and translational modeling. The Pharmacometrics group sits within the company’s Clinical Development organization. Team members get to sit on both Discovery and Development projects and work in a seamless end-to-end environment at the company. The team collaborates closely with clinical development functions (clinical science, clinical operations, regulatory affairs, biostatistics, etc.), as well as discovery functions (DMPK, Biology, Chemistry and Translational Biomarkers).

The Experience You’ll Need

• Ph.D. in Pharmaceutical Sciences, Pharmacokinetics or related discipline, M.D with a Clinical Pharmacology expertise, or a Pharm D. with a Clinical Pharmacology fellowship, with 10+ years of experience in biotech/pharmaceutical drug development.

• Demonstrated success leading all clinical pharmacology related aspects of drug development.

• Ability to work closely with internal and external stakeholders to manage PK, PK-PD, and PK-safety analyses, including non-compartmental analysis, population PK modeling, and PK-PD modeling and simulations to support dose selection, exposure-response and exposure-safety analyses through various phases of drug development.

• Proficiency with WinNonlin, Monolix, NONMEM, R or other modeling software.

• Effective skills directed toward driving collaboration, achieving results, influencing, and resolving conflicts across internal and external stakeholders

• Demonstrated experience responding to regulatory agency questions, preparing clinical pharmacology aspects of regulatory submissions and attending regulatory meetings.

• Highly motivated, decisive, and results-oriented individual who is proactive, resourceful, and efficient with the flexibility and creativity to excel in and contribute to a rapidly growing drug discovery and development company

Experience in oncology is preferred, but not an absolute requirement.

Working Location & Compensation

This is a remote position based in the United Kingdom with required periodic travel.

At the company, we believe that every employee should be compensated fairly. Based on the skills, experience, and qualifications needed for this role, the estimated annual base salary range is: £136,500 –£167,200 . In addition to base salary, this role is eligible for an annual bonus, equity compensation, and a comprehensive benefits package.

#LI-REMOTE

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The Values We Hope You Share

• We act boldly with integrity. We are unconstrained in our thinking, take calculated risks, and push boundaries, but never at the expense of ethics, science, or trust.

• We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up, speaking honestly, and taking action.

• We learn actively and adapt rapidly. Progress comes from doing. We experiment, test, and refine, embracing iteration over perfection.

• We move with urgency because patients are waiting. Speed isn’t about rushing but about moving the needle every day.

• We take ownership and accountability. Through ownership and accountability, we enable trust and autonomy—leaders take accountability for decisive action, and teams own outcomes together.

• We are One the company. True cross-functional collaboration is about trust, clarity, humility, and impact. Through sharing, we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at the company. They are the character and personality of the company demonstrated through how we communicate, support one another, spend our time, make decisions, and celebrate collectively.

More About the company

The company (NASDAQ: RXRX) is a clinical-stage TechBio company decoding biology to radically improve lives. The company is advancing a portfolio of differentiated investigational medicines across its wholly owned and partnered pipeline in oncology, rare disease, neuroscience, immunology, and other therapeutic areas with significant unmet need. Enabling its mission is the company OS, an AI-native, end-to-end drug discovery and development platform integrating biology, chemistry, and clinical development into a unified intelligence system. Powered by proprietary multimodal data, purpose-built AI models, and bilingual teams fluent in both science and AI, the company OS is designed to translate complex science into medicines that matter — faster, better, and at scale — for patients who are waiting.

The company’s platform infrastructure is anchored in Salt Lake City, Utah and Milton Park, Oxfordshire, where its automated biology and chemistry laboratories generate proprietary data at industrial scale. The company also maintains offices in New York, Montréal, and London, three global hubs for talent and leadership at the intersection of AI and scientific innovation. Learn more at [link for members] , or connect on X and LinkedIn .

The company is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other characteristic protected under applicable federal, state, local, or provincial human rights legislation.

Accommodations are available on request for candidates taking part in all aspects of the selection process.

The company leverages AI in our hiring process. We use Greenhouse's Talent Matching AI technology feature to help review applications against the skills and experience we've identified as important for this role. It analyzes your resume and application responses to assess how closely your qualifications match our criteria - but all decisions are made by our human recruiters and hiring managers, including whether to move to the next phase of review. Talent Matching does not automatically advance or reject any candidate.  By submitting your application, you acknowledge that you have been informed about and consent to this use of the Talent Matching tool in our review process. Please refer to the company Privacy Policy at  [link for members] for more information about our processing of personal data and your rights.

Recruitment & Staffing Agencies: the company Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to the company or its employees is strictly prohibited unless contacted directly by the company’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of the company, and the company will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.